If you have more than one image layer there will be more than one pixel at each position. On the screen of course, you see only one colour for each pixel and this colour depends on how all of the pixels through the layers at that position blend with each other.
If the top layer is set to Blend Mode
Normal, then the pixels
underneath will have no effect on what you see on the screen (or print
out for that matter). On the other hand, Blend Mode Multiply
takes the three values (R,G&B) for the pixel in the Blend Layer
(top) and similarly for the Base Layer (bottom), performs a calculation
on them and produces a Result Colour (screen & print) that is
always darker than either of the pixels.
Generally, the easiest way to decide the best blend mode is to cycle through them. You can do this quite quickly as follows:
A few notes on some of the Blend Modes.
For Tinting B/W Images with colour, set the Blend Mode of the duplicated (top) layer to Color and paint on the top layer with colours of your choice. But see my notes on Photoshop Hand Colouring for a lot more ideas.
Change the Opacity of the top layer to adjust the degree of the effect.
A ‘neutral colour’ doesn’t change when you apply the appropriate Blend Mode. These are the neutral colours for some of them.
There is no neutral colour for Normal, Dissolve, Hue,
Saturation,
Color & Luminosity.
If a layer contains White pixels and you set its blend mode to Multiply, then the white pixels become transparent. You can use this technique when you have an image with a completely burned out sky to enable you to reveal a ‘new sky’ layer underneath.